Winter Street Ventures has launched its debut fund, which is targeting $100 million. The Boston-based firm invests in tech-enabled healthcare and AI-driven healthcare solutions companies. It primarily focuses on Series A deals and reserves around 20 percent of its capital to selectively invest in Seed-stage deals.
“Investing in healthcare innovation is not just funding companies, it’s fueling the future of health,” WSV general partner Chris Palmieri said in a statement. “We invest in the companies – and the people and passion behind them – that are transforming real-world challenges into solutions for patients and their families.”
Fund I will target investments in companies with up to $10 million in revenue and pre-money valuations of less than $30 million, and will ideally sit on the boards of the companies it invests in.
Palmieri founded WSV in 2016 as the venture capital affiliate of Massachusetts-based medical insurance provider Commonwealth Care Alliance. Palmieri served as the CCA’s CEO from 2015 to 2025 before stepping down and purchasing the existing portfolio of WSV following the CCA’s acquisition by CareSource in April, establishing WSV as a stand-alone investment firm.
Before spinning out, WSV had built a portfolio of 10 companies including healthcare communication platform Thrive Health Tech and healthcare-focused fintech developer Lynx, according to data from Crunchbase. The firm’s current portfolio has so far generated an MOIC of 5.2x, it said in its statement.
Palmieri, a 30-year veteran in the healthcare industry, is joined by associates Aaron Sells and Jack Santacroce and venture partner Jennifer Bell, the founding partner of healthcare policy consulting firm Chamber Hill Strategies.
